During the course of the mini-series, strange events begin to take place after a large crate is delivered to the Marsten House, which turns out to contain Barlow, actually an ancient master vampire, who has come to the town after having sent his servant (Straker) to make way for his arrival. Various sub-plots are woven into this, including the story of an affair between the real estate agent Larry Crockett and his secretary. Straker cryptically informs Crockett who sold the property to him that he will be rewarded, and Crockett is later attacked by Barlow. Mears and Straker’s arrival coincides with the disappearance of a young boy, Ralphie Glick, and the two (along with Barlow) becomes suspects by Constable Gillespie. The Glick boy returns as a vampire to claim his brother, Danny, who rises from the dead and strikes first at Mike Ryerson and then a friend, Mark Petrie. However, Mark is familiar with the properties of movie vampires, and is able to resist Danny’s hypnotic control.

Slowly, the vampires spread as Mears and Burke figures out what is happening to the town and attempt to do something to stop it. Burke, however, falls prey to a heart attack, following a visit from the vampirised Ryerson. In the end, Susan, along with the Petrie boy have been both captured by Straker after breaking into the Marsten house. Mears and Dr. Norton heads over to end the town’s takeover. Inside the house, Norton is killed by the daily guarding Straker, who is then shot to death by Ben. Afterwards, Mears with Petrie finally destroys Barlow, but Susan is nowhere to be found. Both flee the town after setting it ablaze in the hopes of ‘purifying’ the evil that has engulfed the town.

The mini-series ends where it opened; Mears and Petrie seen two years later at a mission in Central America. They are apparently on the run from the vengeful vampires. Fortunately, they know when the vampires are near when the holy water they keep with them begins to glow. Warned by this phenomenon as they refill their supplies of holy water, Mears and Petrie quickly go to pack their things before fleeing from the mission. However, Mears finds Susan lying in his bed; now a vampire, she prepares to bite Ben, as he leans down to embrace her, but only to mercilessly stake her, though with grief. He and Petrie then leave, with the vampires still on their trail.